Patrick A Baeuerle Selected Research

Cytokines

1/2023	Mesothelin-targeting T cells bearing a novel T cell receptor fusion construct (TRuC) exhibit potent antitumor efficacy against solid tumors.
1/2019	Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.
1/2018	Pharmacokinetic and Pharmacodynamic Relationship of Blinatumomab in Patients with Non-Hodgkin Lymphoma.
6/2009	Antitumor activity of an EpCAM/CD3-bispecific BiTE antibody during long-term treatment of mice in the absence of T-cell anergy and sustained cytokine release.
11/2007	Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class.
10/2007	The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct.
2/2007	Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF.
9/2006	Antitumor activity of a dual cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM expressing tumor cells.
5/2006	T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct.
2/2006	A human cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM overexpressing tumor cells.

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Patrick A Baeuerle Research Topics

Disease

56	Neoplasms (Cancer) 01/2023 - 04/2002
26	Bites and Stings (Sting) 01/2018 - 04/2005
12	Carcinoma (Carcinomatosis) 01/2020 - 07/2002
8	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 05/2011
7	Neoplasm Metastasis (Metastasis) 01/2020 - 08/2003
6	Ovarian Neoplasms (Ovarian Cancer) 12/2023 - 06/2003
6	Lymphoma (Lymphomas) 06/2013 - 03/2007
5	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 06/2003
5	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2018 - 05/2005
4	Autoimmune Diseases (Autoimmune Disease) 05/2024 - 07/2003
4	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 10/2006
4	Melanoma (Melanoma, Malignant) 10/2011 - 02/2006
3	Hematologic Neoplasms (Hematological Malignancy) 01/2020 - 06/2009
3	Leukemia 06/2012 - 06/2009
3	Rheumatoid Arthritis 03/2009 - 07/2004
2	Lung Neoplasms (Lung Cancer) 12/2023 - 05/2009
2	Mesothelioma 12/2023 - 01/2023
2	Persistent Infection 01/2018 - 01/2006
2	Philadelphia Chromosome 04/2016 - 12/2012
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/2014 - 01/2014
2	Residual Neoplasm 12/2012 - 06/2011
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2012 - 05/2005
2	Breast Neoplasms (Breast Cancer) 11/2010 - 05/2005
2	Lung Diseases (Lung Disease) 02/2007 - 02/2007
2	Renal Cell Carcinoma (Grawitz Tumor) 02/2006 - 05/2005
2	Neointima 02/2005 - 04/2004
1	Uveal melanoma 01/2022
1	Triple Negative Breast Neoplasms 01/2021
1	Human Influenza (Influenza) 01/2017
1	B-Cell Leukemia (Leukemia, B Cell) 06/2013
1	Pancreatitis 11/2010
1	Tics (Tic) 10/2010
1	Disease Progression 01/2010
1	Celiac Disease (Celiac Sprue) 03/2009
1	Adenocarcinoma 01/2009

Drug/Important Bio-Agent (IBA)

27	Epithelial Cell Adhesion MoleculeIBA 01/2020 - 06/2003
21	AntibodiesIBA 05/2024 - 07/2003
14	AntigensIBA 01/2022 - 07/2003
13	blinatumomabIBA 01/2018 - 08/2008
10	CytokinesIBA 01/2023 - 02/2006
10	Bispecific AntibodiesIBA 01/2022 - 08/2003
8	T-Cell Antigen Receptors (T-Cell Receptor)IBA 12/2023 - 04/2007
8	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2006
7	Immunoglobulin G (IgG)IBA 11/2010 - 06/2003
6	Surface Antigens (Surface Antigen)IBA 01/2021 - 02/2006
6	Single-Chain AntibodiesIBA 01/2018 - 04/2005
6	EpitopesIBA 01/2011 - 12/2006
6	Monoclonal AntibodiesIBA 08/2010 - 06/2003
5	Chimeric Antigen ReceptorsIBA 01/2023 - 01/2017
4	Peptides (Polypeptides)IBA 01/2022 - 05/2005
4	adecatumumabIBA 11/2010 - 10/2006
4	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 02/2007 - 02/2006
3	MesothelinIBA 12/2023 - 01/2021
3	Interleukin-2 (IL2)IBA 10/2011 - 02/2006
3	Propidium (Propidium Iodide)IBA 01/2009 - 06/2003
2	Neoplasm Antigens (Tumor Antigens)IBA 01/2021 - 01/2020
2	ErbB Receptors (EGF Receptor)IBA 01/2017 - 07/2010
2	AMG 330IBA 06/2014 - 01/2014
2	Carcinoembryonic AntigenIBA 01/2012 - 05/2009
2	Chondroitin Sulfate ProteoglycansIBA 10/2011 - 08/2010
2	HMW-MAAIBA 10/2011 - 08/2010
2	Complement System Proteins (Complement)IBA 11/2010 - 08/2010
2	EdrecolomabIBA 11/2010 - 07/2002
2	Cell Adhesion MoleculesIBA 10/2010 - 07/2009
2	Complementary DNA (cDNA)IBA 07/2008 - 02/2006
2	CD3 ComplexIBA 01/2008 - 04/2007
2	CollagenIBA 07/2007 - 12/2006
2	Sirolimus (Rapamycin)FDA Link 02/2005 - 04/2004
1	tebentafuspIBA 01/2022
1	Serum AlbuminIBA 01/2021
1	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA 01/2021
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2020
1	Human immunodeficiency virus 1 gp120 proteinIBA 01/2018
1	Antiviral Agents (Antivirals)IBA 01/2018
1	LectinsIBA 06/2014
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 06/2014
1	PasotuxizumabIBA 12/2012
1	VaccinesIBA 06/2012
1	CD19 AntigensIBA 06/2011
1	Immunoglobulin IsotypesIBA 05/2011
1	AgarIBA 10/2010
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 10/2010
1	Cetuximab (Erbitux)FDA Link 07/2010
1	Prostate-Specific Antigen (Semenogelase)IBA 01/2010
1	Phospholipases (Phospholipase)IBA 05/2009
1	Rituximab (Mabthera)FDA Link 03/2009
1	CTLA-4 AntigenIBA 02/2009
1	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 01/2009
1	Adenylate KinaseIBA 01/2009

Therapy/Procedure

27	Therapeutics 05/2024 - 04/2002
7	Drug Therapy (Chemotherapy) 01/2014 - 05/2005
6	Immunotherapy 01/2017 - 01/2006
2	Injections 07/2006 - 04/2005
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2023
1	Castration 01/2021
1	Duration of Therapy 01/2018
1	Transplantation 01/2013
1	Intraperitoneal Injections 12/2012
1	Immunomodulation 05/2011
1	Prostatectomy (Retropubic Prostatectomy) 01/2010